Key publications

Peptaibiotics

  • Peptides on the Surface. PELDOR Data for Spin-Labeled Alamethicin F50/5 Analogues on Organic Sorbent. A.D. Milov, R.I. Samoilova, Y.D. Tsvetkov, C. Peggion, F. Formaggio, C. Toniolo. J. Phys. Chem. B, 2014, 118, 7085-7090.
  • Spectroscopically Labeled Peptaibiotic Analogs: the 4-Nitrophenylalanine Infrared Absorption Probe Inserted at Different Positions into Trichogin GA IV. C. Peggion, B. Biondi, M. De Zotti, S. Oancea, F. Formaggio, C. Toniolo. J. Pept. Sci., 2013, 19, 246-256.
  • Trichogin GA IV: A Versatile Template for the Synthesis of Novel Peptaibiotics. M. De Zotti, B. Biondi, C. Peggion, F. Formaggio, Y. Park, K.-S. Hahm, C. Toniolo. Org. Biomol. Chem., 2012, 10, 1285-1299.
  • Main-Chain Length Control of Conformation, Membrane Activity, and Antibiotic Properties of Lipopeptaibol Sequential Analogues. S. Oancea, G. Hilma, C. Peggion, F. Formaggio, C. Toniolo. Chem. Biodivers., 2008, 5, 681-692.
  • Crystal Structure of a Spin-Labeled, Channel-Forming Alamethicin Analogue. M. Crisma, C. Peggion, C. Baldini, E.J. Mac Lean, N. Vedovato, G. Rispoli, C. Toniolo. Angew. Chem. Int. Ed., 2007, 46, 2047-2050.
  • Lipopeptaibols, a Novel Family of Membrane Active, Antimicrobial Peptides. C. Toniolo, M. Crisma, F. Formaggio, C. Peggion, R.F. Epand, R.M. Epand. Cell. Mol. Life Sci., 2001, 58, 1179-1188.

Antimicrobial textiles

Anticancer peptides

  • The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. A. Dalzini, C. Bergamini, B. Biondi, M. De Zotti, G. Panighel, R. Fato, C. Peggion, M. Bortolus, A.L. Maniero. Scientific Reports, 2016, 6, 24000.
  • The peculiar N- and C-termini of trichogin GA IV are needed for membrane interaction and human cell death induction at doses lacking antibiotic activity, BBA Biomembranes, 2015, 1848, 134-144.
  • Conjugation of photosensitisers to antimicrobial peptides increases the efficiency of photodynamic therapy in cancer cells, Photochem. Photobiol. Sci. 2015, 14 1238-1250
  • Synthesis, characterization and biological evaluation of a dual action ligand targeting αVβ3 integrin and VEGF receptors, ChemistryOpen, 2015, 4, 633-641 

Structural studies

  • Helical Foldamers Incorporating Photoswitchable Residues for Light-Mediated Modulation of Conformational Preference. D. Mazzier, M. Crisma, M. De Poli, G. Marafon, C. Peggion, J. Clayden, A. Moretto. J. Am. Chem. Soc., 2016.
  • Peptide δ-Turn: Literature Survey and Recent Progress. C. Toniolo, M. Crisma, A. Moretto, C. Peggion, F. Formaggio, C. Alemán, C. Cativiela, C. Ramakrishnan, P. Balaram. Chem. Eur. J., 2015, 21, 13866-13877.
  • Single and Multiple Peptide g-Turns: Literature Survey and Recent Progress. M. Crisma, M. De Zotti, A. Moretto, C. Peggion, B. Drouillat, K. Wright, F. Couty, C. Toniolo, F. Formaggio. New Journal of Chemistry, 2015, 39, 3208-3216.
  • Synthesis and Conformational Study of Model Peptides Containing N-Substituted 3-Aminoazetidine-3-carboxylic Acids. A. Žukauskaitė, A. Moretto, C. Peggion, M. De Zotti, A. Šačkus, F. Formaggio, N. De Kimpe, S. Mangelinckx. Eur. J. Org. Chem., 2014, 2312-2321.

Nanoparticles and Materials

  • A terminally protected dipeptide: from crystal structure and self-assembly, through co-assembly with carbon-based materials, to a ternary catalyst for reduction chemistry in water, Soft Matter, 2016, 12, 238-245
  • Synthesis and Photochemical Applications of Processable Polymers Enclosing Photo luminescent Carbon Quantum Dots, ACS Nano, 2015, 9, 4156-4164
  • Mimicking Nature: A Novel Peptide-based Bio-inspired Approach for Solar Energy Conversion, ChemPhysChem, 2014, 15, 64-68