Expertise

Peptide synthesis 
in solution

  • Difficult syntheses
  • Coupling of  sterically  hindered amino acids
  • New coupling reagents
  • Fragment condensation
  • Native Chemical Ligation

Solid phase peptide synthesis 

  • New resins
  • Side chains built on the resin
  • New orthogonalities
  • Manual and authomatic SPPS

Function-activity relationship 

  • Liposome preparation
  • Leakage
  • Enzymatic degradation
  • Fluorescence

Conformational 
studies 

  • Conformation ↔ Activity
  • Action mechanisms
  • 1D,  2D and 3D NMR spectroscopy
  • FT-IR absorpion
  • X-RAY diffraction
  • Circular Dichroism
  • Modelling

Equipment

Synthesis

SAP (BIOTAGE)
Syro Wave (BIOTAGE)
ACT 348 (Advanced ChemTech)

Purification

HPLC systems (AGILENT, SHIMADZU, Hitachi)
Isolera (BIOTAGE)

Structure

NMR 400MHz (Bruker)
NMR 600MHz (Bruker)

CD (Jasco J715)

X-ray diffractometer (Gemini, Rigaku Oxford Diffraction)"

FT-IR spectrophotometer (Nicolet Nexus) 

Fun

food
wine
cakes